A tiered hidden Markov model characterizes multi-scale chromatin states
نویسندگان
چکیده
منابع مشابه
Multi-scale chromatin state annotation using a hierarchical hidden Markov model
Chromatin-state analysis is widely applied in the studies of development and diseases. However, existing methods operate at a single length scale, and therefore cannot distinguish large domains from isolated elements of the same type. To overcome this limitation, we present a hierarchical hidden Markov model, diHMM, to systematically annotate chromatin states at multiple length scales. We apply...
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ژورنال
عنوان ژورنال: Genomics
سال: 2013
ISSN: 0888-7543
DOI: 10.1016/j.ygeno.2013.03.009